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Several of these studies involved patients stabilized on an 26 buy discount viagra super active 100 mg on-line erectile dysfunction young adults treatment, 32 29 cheap 50mg viagra super active amex erectile dysfunction treatment nz, 30, 35 ACE-I, while others included only subjects with no recent use of ACE-Is or AIIRAs. The largest of the 5 trials included only 166 26 26, 32, 35 patients. The 3 parallel-group studies were all of monotherapy, while 1 cross-over 30 study (N=20) included a placebo, monotherapy with either losartan or enalapril, and a combination group. The other cross-over study included a placebo arm, both drugs as 29 monotherapy, and both monotherapies combined with aspirin. Three of these studies were of 26, 30 32 29, 35 fair quality and 2 were of poor quality. The quality of the body of evidence for the outcomes of quality of life and exercise capacity were assessed as low due to concerns regarding risk of bias and small sample sizes. Other outcomes were not assessed for quality as no more than 1 study examined other relevant outcomes. Exercise capacity improved with both losartan and enalapril, with no significant 26, 29, 32 difference between monotherapy treatment groups. Symptoms also improved in 1 study, with no significant difference between monotherapy groups, although the incidence of 26 pulmonary rales increased more with losartan 50 mg than with enalapril 20 mg daily (P<0. In that same study, the dyspnea-fatigue index improved with lisinopril 25 mg only (P=0. Minor increases in serum creatinine, 26 32 blood urea nitrogen, and potassium were reported with enalapril compared with losartan, but were not considered clinically significant. Cough was only reported in 1 study, with no 26 significant differences between enalapril and losartan 25 and 50 mg daily. Subgroups There were no significant interactions between treatment and subgroups based on age, sex, and 26, 32 New York Heart Association functional class in 2 studies examining subpopulations. Telmisartan compared with enalapril (monotherapy plus diuretic) (n=1) 28 The REPLACE (the replacement of angiotensin converting enzyme inhibition) trial involved patients with stable heart failure on a diuretic and enalapril 10 mg twice daily who were then randomized to continuation of enalapril 10 mg twice daily or to various telmisartan dosages (10, 20, 40, 60 mg daily). There was no significant difference within any treatment group at 12 weeks of follow-up, nor were there any significant differences between any telmisartan group and enalapril for exercise duration, New York Heart Association classification, or quality of life. Rates of 1 or more adverse events were reported as similar across treatment groups (overall rate of 54%), but group-specific rates were not reported. Cough was more common with enalapril, but not significantly different from rates with telmisartan (P=0. Telmisartan compared with ramipril (monotherapy and combination therapy) (n=1) A large, double-blind, non-inferiority, randomized, good-quality trial (N=25 620) compared ramipril 10 mg daily, telmisartan 80 mg daily, and combination therapy in patients with vascular disease or diabetes with end-organ damage but without symptomatic heart failure (ONTARGET, 31 The Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial). At a median follow-up of 56 months, telmisartan was not inferior to ramipril for the prespecified primary outcome of death from cardiovascular causes, myocardial infarction, stroke, or hospitalization for heart failure (relative risk, 1. Results were also consistent across all components of this outcome. In addition, telmisartan was not inferior to ramipril for the secondary composite outcome of death from cardiovascular causes, myocardial infarction, or stroke (the primary outcome of the HOPE trial) (relative risk, 0. There were no significant differences between ramipril and telmisartan in deaths, revascularization, hospitalization or worsening or new angina, new diagnosis of diabetes, or heart failure. In ONTARGET, combination therapy with telmisartan and ramipril was not significantly better than ramipril alone for the primary outcome (relative risk, 0. DRIs, AIIRAs, and ACE-Is Page 27 of 144 Final Report Drug Effectiveness Review Project For the secondary outcome of renal impairment (no specific definition was used, rather the definition was based on report of an event that led to discontinuation of the drug), ramipril 31 and telmisartan had a similar relative risk (1. The relative risk of renal impairment with combination therapy was, however, significantly increased (1. Rates of renal dialysis were not significantly different across the 3 treatment groups. For the primary renal composite outcome of dialysis, doubling of serum creatinine, and death, event rates were similar for telmisartan and ramipril, but were increased 41 with combination therapy (hazard ratio, 1. The secondary renal outcomes of dialysis or doubling of creatinine were also similar with the 2 monotherapies, but increased with combination therapy (hazard ratio, 1. On the other hand, the increase in urinary albumin excretion was less with telmisartan (P=0. Harms More subjects permanently discontinued ramipril as monotherapy or combination therapy because of cough or angioedema than telmisartan monotherapy. More subjects stopped telmisartan due to hypotension symptoms than ramipril. Discontinuation due to hypotension, syncope, diarrhea, or renal impairment was more likely to occur with combination therapy than 31 with ramipril monotherapy (P<0.

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R andomiz ation cheap 25mg viagra super active free shipping erectile dysfunction exercises treatment,treatmentallocation discount viagra super active 25 mg amex impotence 20s, C yclobenz aprine vs. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition A uth or F unding Source O th er Y ear A dverse events and R ole com m ents Boyles C arisoprodolvs. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition Interventions Screened A uth or Type ofStudy, Dose Eligible Y ear Setting Duration Eligibility C riteria ExclusionC riteria Enrolled F ryda- R andomiz ed A : Tiz anidine 4-8 mgpo tid Inpatients with acute N otreported N otreported K aurimsky trial muscle spasm due to 130 B: Diaz epam 5-10 mgpo tid degenerative spinaldisease N otreported 1981 G ermany 10 days 20 Single center H ennies R andomiz ed A : Tiz anidine 4 mgtid A cute painfulcervicalor L iverorrenaldisease, N otreported 131 trial lumbarspasm cardiovasculardisease,active 1981 B: Diaz epam 5 mgtid infectionormalignancy in N otreported G ermany spine,rh eumaticdisease, 7 day psych ologically unstable,or 30 Single center pregnant Preston R andomiz ed A : C yclobenz aprine 10 mgpo tid L ocaliz ed muscle spasm Spasm due to disease ofth e N otreported 20 trial due to painsecondary to spinalcord,cerebraldisease, 1984 B: M eth ocarbamol1500 mgpo qid traumaticorinflammatory psych ologicalcauses;no 232 U. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition W ith drawals orlostto follow- A uth or up M eth od ofO utcom e A ssessm entand Tim ing of Y ear A nalyz ed PopulationC h aracteristics A ssessm ent F ryda- N one reported Tiz anidine vs. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition A uth or Y ear O verallR ating and com m ents O utcom es F ryda- F A IR. R andomiz ation,treatmentallocation,and Tiz anidine vs. R andomiz ationand allocationconcealment Tiz anidine vs. R andomiz ation,allocationconcealment C yclobenz aprine vs. B) Interference with daily activities (absentormild): 41% vs. B) Skeletal Muscle Relaxants Page 175 of 237 Final Report Update 2 Drug Effectiveness Review Project Evidence Table 5. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition A uth or F unding Source O th er Y ear A dverse events and R ole com m ents F ryda- Tiz anidine vs. Diz z iness: N one reported W eakness: N one reported Dry mouth : N one reported Preston C yclobenz aprine vs. C N S adverse event(includingdrowsiness,diz z iness): R esults only 60/87 (58% )vs. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition Interventions Screened A uth or Type ofStudy, Dose Eligible Y ear Setting Duration Eligibility C riteria ExclusionC riteria Enrolled R ollings R andomiz ed A : C yclobenz aprine 10 mgpo qid O utpatients between19 and C ervicalstrain,patients N otreported 124 trial 65 with acute back strain involved inlitigation,pregnant 1983 B: C arisoprodol350 mgpo qid (no neck involvement), women,nursingmoth ers, N otreported U. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition W ith drawals orlostto follow- A uth or up M eth od ofO utcom e A ssessm entand Tim ing of Y ear A nalyz ed PopulationC h aracteristics A ssessm ent R ollings 20 C yclobenz aprine vs. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition A uth or Y ear O verallR ating and com m ents O utcom es R ollings F A IR : H igh loss to follow-upand no intention-to- C yclobenz aprine vs. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition A uth or F unding Source O th er Y ear A dverse events and R ole com m ents R ollings C yclobenz aprine vs. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition Interventions Screened A uth or Type ofStudy, Dose Eligible Y ear Setting Duration Eligibility C riteria ExclusionC riteria Enrolled Sch einer R andomiz ed A : C yclobenz aprine 30-40 mg/day M oderate to severe neck or O th erserious medicalor N otreported 128 trial low back muscle spasm of psych iatricconditions,spasticity 1978 (1) B: Diaz epam 15-20 mg/day localoriginand recent(<30 ofneurologicorigin,pregnant N otreported U. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition W ith drawals orlostto follow- A uth or up M eth od ofO utcom e A ssessm entand Tim ing of Y ear A nalyz ed PopulationC h aracteristics A ssessm ent Sch einer 18 C yclobenz aprine vs. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition A uth or Y ear O verallR ating and com m ents O utcom es Sch einer F A IR : R andomiz ationand allocationconcealment C yclobenz aprine vs. M eanimprovementinscore atweeks 1 and 2 1978 (2) M uscle spasm: 1. H ead-to-h ead trials ofskeletalm uscle relaxants inpatients with m usculoskeletalcondition A uth or F unding Source O th er Y ear A dverse events and R ole com m ents Sch einer C yclobenz aprine vs. Placebo-controlled trials ofskeletalm uscle relaxants inpatients with m usculoskeletalconditions Interventions Enrolled A uth or Type ofStudy,Dose Eligibility M eth od ofO utcom e A ssessm entand Tim ing Y ear Setting Duration C riteria A nalyz ed PopulationC h aracteristics ofA ssessm ent A iken R andomiz ed A : C yclobenz aprine O utpatients with 50 C yclobenz aprine vs. Placebo-controlled trials ofskeletalm uscle relaxants inpatients with m usculoskeletalconditions A uth or O verallR ating and Y ear com m ents O utcom es A dverse Events A iken F A IR. Placebo-controlled trials ofskeletalm uscle relaxants inpatients with m usculoskeletalconditions Interventions Enrolled A uth or Type ofStudy,Dose Eligibility M eth od ofO utcom e A ssessm entand Tim ing Y ear Setting Duration C riteria A nalyz ed PopulationC h aracteristics ofA ssessm ent Baratta R andomiz ed A : C yclobenz aprine M oderate-severe 120 C yclobenz aprine vs. L imitationofactivities ofdaily living notreported 10 days oruntil 118 acute musculoskeletalstrain *A llrecorded using5-pointratingscale patientbecame 2 post-traumaticorigin (1=absentto 5=severe) asymptomatic M oderate-severe spasticity A ssessment#1 completed 2-3 h ours post-first Previous muscle relaxantuse not dose oftestdrug;#2 with indays 2-4;#3 with in reported days 5-7;#4 with indays 8-12 Basmajian R andomiz ed A : C yclobenz aprine A cute 205 enrolled A ge,gender,race notreported Pain,spasm,tenderness,range ofmotion, 144 5 mgbid musculoskeletal forallarms activities ofdaily living: meth ods ofassessment 1989 C anada painwith C linicalconditions notreported notreported B: Placebo associated spasm 175 analyz ed 18 centers ofth e neck orlow (Diflunisaland back 88 in C yclobenz aprine + cyclobenz aprin diflunisalarms e orplacebo excluded) arms 7-10 days Skeletal Muscle Relaxants Page 187 of 237 Final Report Update 2 Drug Effectiveness Review Project Evidence Table 6. Placebo-controlled trials ofskeletalm uscle relaxants inpatients with m usculoskeletalconditions A uth or O verallR ating and Y ear com m ents O utcom es A dverse Events Baratta F A IR. Placebo W ith drawal(due to adverse events): 0 142 concealmentmeth od not 1982 reported.

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Mainly smoking but also life-style (alcohol viagra super active 25 mg for sale erectile dysfunction treatment germany, UV exposure) or coinfections (HPV cheap 25mg viagra super active visa over the counter erectile dysfunction pills uk, HBV, HCV) contribute to the risk. In the absence of smoking, however, the increase in risk is confined to cancers related to viral infections, whereas the risk of other cancers is not elevated and does not seem to be associated with immune deficiency (Helleberg 2014). Given the fact that HIV+ patients are aging, an increase of incidences of malignancies is to be expected (Shiels 2011). ART seems to have little influence on the occurrence of non-ADMs since therapy interruption does not increase the risk for non-ADMs, in contrast to ADMs (Silverberg 2007). Early diagnosis and prevention It remains unclear whether HIV+ patients require cancer screening and preventive medical checkups more frequently than negative patients. There are some indica- tions for a benefit regarding anal carcinomas (see below). Regarding colon carcinoma the situation is not clear; however, there is evidence that neoplastic changes are found more frequently in colorectal cancer screening with HIV+ patients (Bini 2009, Boesecke 2012). This examination, however, is not so popular with HIV+ patients or with treating physicians. Compared to the HIV-negative population, colorectal cancer screening is utilized to a lesser degree (Reinhold 2005). With respect to PSA screening, which is discussed controversially in general, there is no specific recom- mendation for HIV+ patients (Tyerman 2012). Gynaecological examinations are dis- cussed in the chapter HIV and Gynaecology. In patients coinfected with HCV, bi- annual ultrasound sonographies can have a benefit, as a recent study with 70 patients showed: hepatocellular carcinomas were less progressed at diagnosis in regularly screened patients resulting in a slightly better survival (Nunez 2010). Finally, physicians should inform patients about the advantages of not smoking and support smoking cessation. Smoking contributes to substantial morbidity and mor- tality in the HIV+ population (Lifson 2010). Patients often request and insist upon more medical checkups, but it is repeatedly forgotten that abstinence from smoking is still the most important preventive measure for malignant diseases. In a setting where care is well organized and antiretroviral therapy is free of charge, HIV+ smokers lose more life-years to smoking than to HIV. The population-attrib- utable risk of death associated with smoking is doubled compared to the background population (Helleberg 2013). In the absence of smoking, the increase of many cancers is not elevated and does not seem to be associated with immune deficiency (Helleberg 2014). Thus, smoking cessation, avoidance of obesity and a healthy lifestyle are more helpful than expensive medical examinations. Treatment One problem in the therapy of non-ADMs is that too little is known about chemother- apeutic substances and their interactions with ART. Especially since the new targeted substances have mostly not been investigated in HIV+ patients. There are no prospec- tive studies and very little data on imatinib, erlotinib, sunitinib, bortezomib, 446 AIDS sorafenib or temsirolimus (Review: Rudek 2011). In most cases patients are younger compared to the HIV-nega- tive population which may be due to better monitoring (Shiels 2010). Publications over the last years on different entities such as glioblastoma (Hall 2009) or colon carcinoma (Chapman 2009, Alfa-Wali 2011), bladder cancer (Gaughan 2009), prostate cancer (Pantanowitz 2008) or esophageal cancer (Stebbing 2010) show that HIV+ patients prosper from the recent and amazing progress made in the oncolog- ical field. There should be no difference in treatment of HIV+ and non-infected patients – however, oncologists often need to be properly informed in order to avoid adhering to an outdated and pessimistic concept of HIV treatment. Anal carcinoma Anal cancer (AC) is probably the most frequent non-ADM. There is a close associa- tion to infections with human papilloma virus (HPV). An overwhelming number of studies and reviews has been published over the last decade, including several reports on dramatic increases of the AC incidence in HIV+ MSM.

F orpost-operativeanalgesia order 25mg viagra super active free shipping impotence xanax,m eperidineim 50m g wasadm inisteredif painscorewas ≥ 5 order viagra super active 25mg with visa erectile dysfunction code red 7. Study alsoincludedam etoclopram idearm (n= 24)andaplaceboarm (n= 29),buttheseresultsarenotincludedinthisdataabstraction. Afterintubation theconcentrationsof thenitrousox ide,ox ygen,carbondiox ide,andisofluraneweredeterm inedcontinuouslybyam ultiple-gasanaesthesia m onitor. Abdom inalinsufflationforthelaparoscopic procedurewasaccom plishedwith carbondiox ide. Antiemetics Page 339 of 492 Final Report Update 1 Drug Effectiveness Review Project Evidence Table 9. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear A llow oth er R un-in/ Setting Design Exclusioncriteria Intervention m edication W ash out O ksuz R CT,D B, Thosewith cardiovascular,pulm onary,renal,hepatic or M etoclopram ide10m g R escuem edicationwas N R /N o 2007 Parallel neurologic diseaseswereex cluded. Aswellasthose G ranisetron40m cg/kg perm itted antiem etic within N R receiving drugsknow tohaveantiem etic effects,such as O ndansetron15m cg/kg iv 48hoursof tricyclic antidepressants,scopolam ine,phenothiaz ines, surgery laraz epam ,corticosteroids,andtrim ethobenz am ides;had ex periencednauseaorvom iting,orwhohadreceived antiem etic treatm entinthe48hoursbeforesurgery. W h ite R CT,ACT,Ptswith historyof allergytoanyof thepotentialstudy G ranisteron(1m g) D ex am ethasone4m g N R /N o 2006 D B m edications,pregnancy,breastfeeding,active O ndansetronIV (4m g) IV giventoallafter antiem etic or M ulticenter m enstruation,vom iting orretching within24h beforethe induction psychoactive U SA operation,adm inistrationof antiem etic orpsychoactive m edication m edicationwithin24h beforesurgery,ahistoryof severe Cisatracurium 0. M etocloparm ide10m g IV wasusedasrescue therapy O ndansetron: O DT vs IV Antiemetics Page 340 of 492 Final Report Update 1 Drug Effectiveness Review Project Evidence Table 9. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or A ge/ Screened/ W ith drawn/ Y ear G ender/ Eligible/ L ostto fu/ Setting Eth nicity Enrolled A nalyz ed O th erpopulationch aracteristics O ksuz 39. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear Setting R esults A dverse Events O ksuz Incidenceof PO N V (0-3h aftersurgery) N R 2007 M et:12% vsG ran:0% vsO nd:12% N R Incidenceof PO N V (4-24h aftersurgery) M et:44% vsG ran:4% vsO nd:12% (p<0. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear Setting C om m ents O ksuz 2007 N R W h ite Subanalysisof outpatientvsinpatient. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear A llow oth er R un-in/ Setting Design Exclusioncriteria Intervention m edication W ash out Dem iraran R CT,D B Thosewhohadex periencednauseaorvom iting 24hours O D T ondansetron8m g and5 M etoclopram ide10m g N R /N R 2005 beforethestudyorwhoweretaking antiem etic m edication m L norm alsalineIV IV wasusedasrescue SingleSite m edication Turkey IV ondansetron4m g in5m L salineandoralplacebo Placebo:5m lnorm alsalineIV andoralplacebo Pirat R CT,D B Ptswith historyof m otionsicknessorPO N V,preoperative O D T ondansetron8m g and5 IM injectionof N R /N o 2005 pruritus,treatm entwith opioidsorantiem eticswithin48 m L norm alsalineIV diclofenac sodium antiem etic within N R hoursof surgery,hypersensitivitytoondansetron, 100m g wasusedfor 48hoursof m orphine,orbupivacaine,andcontraindicationforor IV ondansetron4m g in5m L postoperativepain surgery refusalorspinalanesthesia. Casesinwhich dural salineandoralplacebo puncturecouldnotbeperform edoropioidswererequired R escuem edicationwas tocontrolintraoperativeorpostoperativepainwerealso Placebo:5m lnorm alsalineIV perm itted ex cluded. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or A ge/ Screened/ W ith drawn/ Y ear G ender/ Eligible/ L ostto fu/ Setting Eth nicity Enrolled A nalyz ed O th erpopulationch aracteristics Dem iraran 47. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear Setting R esults A dverse Events Dem iraran O D T vsIV vsPla O D T vsIV vsPla 2005 Incidenceof nauseaorvom iting (1stm in) Headache:13% vs17% vs15% SingleSite N ausea:28% vs25% vs55% (p<0. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear Setting C om m ents Dem iraran D atapresentedingraphs,num bersareestim atesof thegraphs. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear A llow oth er R un-in/ Setting Design Exclusioncriteria Intervention m edication W ash out Diem unsch R CT,D B E x clusioncriteriaincludedpregnancy/breastfeeding Aprepitant40m g,orally Prem edication,as N o/no 2007 status,needforanasogastric ororal-gastric tube,useof Aprepitant125m g,orally needed prophylactic M ulticenter neuroax ial-orpropofol-m aintainedanaesthesia,vom iting O ndansetron4m g iv antiem etics within24h beforesurgeryorof anyorganic aetiology, rescuem edication within24h allergytoanym edicationstobeusedbeforeoperationor (chosenby beforesurgery intra-operatively,pre-establishedneedforintensivecare investigator) orstep-downunitcareafteroperation,evidenceof diseaseorhistoryof illnesswhich according tothe investigatorrenderedthepatientinappropriateforthe study,abnorm alpreoperativelaboratoryvalues(aspartate am inotransferase>2. M edicationsknowntoinduceCYP3A4were prohibitedwithin30daysof thestudystartandCYP3A4 inhibitorswereprohibited7daysbeforestartof study. G an R CT,D B Patientswhowerepregnantorbreast-feeding,undergoing Aprepitant40m g orally R escuem edicationwas N o/no 2007 surgeryrequiring routineplacem entof anasogastric or Aprepitant125m g orally perm itted prophylactic M ulticenter oral-gastric tube,orreceiving spinalregionalorpropofol- O ndansetron4m g iv antiem etics m aintainedanesthesia. Ptswhom werevom iting of any within24hours organic etiology,hadvom itedforanyreasonwithin24 beforesurgery hoursof surgery,orhadabnorm allaboratoryvaluesas specifiedbytheprotocol(alanineam inotransferaseof aspartateam inotransferase>2. Thosetaking m edicationsm etaboliz edbyCYP3A4wereex cluded. Dolasetronvs G ranisetronvs O ndansetron Antiemetics Page 348 of 492 Final Report Update 1 Drug Effectiveness Review Project Evidence Table 9. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or A ge/ Screened/ W ith drawn/ Y ear G ender/ Eligible/ L ostto fu/ Setting Eth nicity Enrolled A nalyz ed O th erpopulationch aracteristics Diem unsch 45. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear Setting R esults A dverse Events Diem unsch Aprepitant40m g vsAprepitant125m g vsO ndansetron4m g M ostcom m onAE sreported: 2007 Com pleteR esponse Pyrex ia:8. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear Setting C om m ents Diem unsch 2007 M ulticenter G an 2007 M ulticenter Dolasetronvs G ranisetronvs O ndansetron Antiemetics Page 351 of 492 Final Report Update 1 Drug Effectiveness Review Project Evidence Table 9. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear A llow oth er R un-in/ Setting Design Exclusioncriteria Intervention m edication W ash out B ridges D B,R CT Allergyto5-HT3R A drugsorpreviousintolerance, D olasetron12. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or Y ear A llow oth er R un-in/ Setting Design Exclusioncriteria Intervention m edication W ash out C h ildren Dolasetronvs. O ndansetron K aram anlioglu D BR CT Childrenwhoreceivedantiem eticsorantihistam inesinthe D olasetronpo1. Anychild unabletoswallow them ethylenebluecapsuleorthestudy drugsorwhovom itedthem beforetheinductionof anesthesiawasex cludedfrom thestudy. Antiemetics Page 356 of 492 Final Report Update 1 Drug Effectiveness Review Project Evidence Table 9. Preventionofpostoperative nauseaand vom iting:H ead-to-h ead trials A uth or A ge/ Screened/ W ith drawn/ Y ear G ender/ Eligible/ L ostto fu/ Setting Eth nicity Enrolled A nalyz ed O th erpopulationch aracteristics C h ildren Dolasetronvs.

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